The University of South Alabama (USA), officially nicknamed "South" is a public, national research university in Mobile, Alabama, United States. It was created by the Alabama Legislaturein May, 1963, and replaced existing extension programs operated in Mobile by the University of Alabama. Currently, USA is divided into ten colleges and schools and includes one of Alabama's two state-supported medical schools. As of the fall semester of 2018, South Alabama has an enrollment of 14,834 students. To date, the university has awarded over 90,000 degrees.

USA has an annual payroll of more than $400 million (US), with over 6,000 employees, and is the second largest employer in Mobile. The University of South Alabama has an annual economic impact of US$3 billion.