Southern has one campus located at 501 Crescent Street, in New Haven, bordering parts of Hamden, Connecticut. Fitch Street separates the academic and residential sections of the campus. The School of Business was moved to the renovated former student center in mid-2012. The building houses meeting rooms, offices for faculty, and trading rooms. As part of an effort to expand on the university's science programs, the laboratory science building was opened in 2015. The four-story building specializes with cancer research, physics and optics, along with other fields of sciences.

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